Systematic Review of Platelet-Rich Fibrin Grafts in the Odontectomy of Lower Third Molars. Case Report

Abstract

In 2001, a second-generation blood concentrate called Platelet-Rich Fibrin (PRF) was developed with numerous advantages and no need for anticoagulants. It was first developed in France by Choukroun for oral and maxillofacial surgery, emerging as an alternative to Platelet-Rich Plasma (PRP). PRF has gained attention in dental research after several key publications in 2006. The fibrin matrix, which is the final product of the coagulation cascade, is the activated form of the plasma molecule fibrinogen. PRF is strictly autologous, obtained by centrifuging the patient’s own blood, which eliminates allergic reactions, disease transmission risks, and donor-site morbidity. Additionally, it is simple to obtain and not expensive. PRF plays an important role after its placement at the dental extraction site. Wisdom tooth extraction is a common oral surgical procedure, and PRF is used to reduce postoperative complications such as pain, inflammation, trismus, and general oral dysfunction during healing. Research by Ozkan Ozgul et al. showed that PRF significantly reduced vertical and horizontal inflammation but had no significant effect on pain. In contrast, Yun He et al. reported that PRF placement at the extraction site significantly decreased both pain and inflammation by the third day after surgery. The objective of this research is to evaluate the benefits of PRF following the extraction of lower third molars. The study includes a systematic review of the literature and a clinical case report, based on articles published until October 2024, analyzing PRF’s role in tissue regeneration and healing.