Effectiveness of intraosseous Platelet Rich Plasma in the treatment of subchondral bone lesions of the knee

Abstract

Knee conditions are one of the main reasons for medical consultations, and they represent a significant functional limitation for patients. One of the treatments for knee conditions that has shown the most effectiveness in these injuries is the use of Platelet-Rich Plasma (PRP), which can help stimulate or accelerate the repair and/or regeneration of various tissues. This is a multicenter, observational, descriptive, retrospective study conducted from January 2021 to January 2024. Of the participants, 52.9% were male and 47.1% were female. The predominant age group was between 50 and 70 years, accounting for 63.2%. A total of 39.7% of participants reported experiencing pain at night, followed by 36.8% who reported all the evaluated symptoms. The right knee was affected in 41.2% of cases. The treatment involved administering PRP + 0.2 cc calcium chloride in a single dose to 52.9% of the sample. The PRP preparation method used calcium chloride as an activation factor, applied with a closed technique, with a centrifugation time of 8 minutes and a speed of 1902 rpm. The most effective dose resulted in a reduction of pain within the first week in 82.4% of cases, and this effect was observed in patients who received a dose of 2 cc. Based on the results, the most effective dose was 2 cc, which performed better than the other doses. However, further studies are needed to obtain results that will allow the standardization of PRP treatment for knee injuries.