Malignant Brenner's tumor. Clinical case

Abstract

Brenner tumors are ovarian neoplasms composed of transitional ovarian cells covered by dense fibrous tissue. Most of these are small tumors less than 2 cm. Incidentally detected in asymptomatic women. Malignant Brenner tumor is a rare histologic subtype of epithelial ovarian cancer, accounting for less than 1% of all ovarian neoplasms. The objective is to present a clinical case of a patient with a giant ovarian tumor whose histology reports malignant Brenner tumor. Malignant Brenner tumor presents similarly to other ovarian neoplasms with abdominal pain and nonspecific symptoms. Diagnosis of the malignant variant includes clear invasion of the stroma by epithelial cells with a characteristic coffee bean nucleus, longitudinal grooves, and pale cytoplasm. Similarly, in the cases reviewed, the tumor size does not exceed 12 cm in length. Malignant Brenner tumors are rare, sometimes their diagnosis can be delayed because they are asymptomatic, they are usually diagnosed as a casual finding within another ovarian lesion, in addition to the fact that imaging is not specific.