Clinical-epidemiological characterization of patients with hyperprolactinemia and prolactin producing pituitary adenomas

Abstract

Hyperprolactinemia is a frequent diagnosis in endocrinology consultation, of pituitary adenomas, prolactinomas are the most frequent cause of hyperprolactinemia. We reviewed patients with idiopathic hyperprolactinemia and prolactinomas evaluated in Centro Médico Docente La Trinidad Endocrinology Service. This was a descriptive, retrospective observational study establishing idiopathic hyperprolactinemia and prolactinomas, demographic and clinical characteristics. Hyperprolactinemia was more frequent in females  with a 4:2 proportion, in prolactinomas 3 women were affected for every male. Average of diagnosis was 37 years from females and 45 for men. Prolactinomas were responsible for hyperprolactinemia in 67.44%, mostly microadenomas 68.9%. Macroadenomas were present in 9 patients (31.03%), 8 of them were treated surgically. Clinical symptoms and comorbidities in the 43 patients with hyperprolactinemia were: menstrual irregularities, dyslipidemia and overweight. Average prolactin was in relation to tumor volume. All patients received cabergoline, 8 underwent surgery. Presenting sequelae more in relation to tumor size than surgery.